THE MULTIPLE MECHANISMS OF PENICILLIN RESISTANCE
نویسندگان
چکیده
منابع مشابه
Mechanisms of acquired penicillin-resistance in Streptomyces cacaoi. Role of penicillin-binding proteins in penicillin resistant mutants.
Several mutants isolated after N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis of Streptomyces cacaoi strain KCCS-0352, were resistant to benzylpenicillin ranging in concentration from 1,000 to 5,000 micrograms/ml (4- to 20-fold more resistant than the parent). These mutants also acquired resistance to mecillinam, cephamycin C and methicillin. The affinity for beta-lactams of penicillin-bindin...
متن کاملPenicillin resistance in gonorrhoea.
The incidence of gonorrhoea in Great Britain reached its peak in 1946, one year after the second World War had ended. Thereafter it declined sharply and continued to do so until 1955, when for the first time since the war the Annual Report of the Chief Medical Officer of the Ministry of Health (1957) indicated an increase in the number of patients with'gonorrhoea attending the clinics. The rise...
متن کاملMolecular mechanisms in multiple myeloma drug resistance.
Multiple myeloma (MM) is predominantly an incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. MM is a genetically heterogeneous disease and the complexity increases as the disease progresses to a more aggressive stage. MM arises from a plasma cell, which produces and secretes non-functioning immunoglobulins. Most MM cells are sensitive to prote...
متن کاملOvercoming multiple drug resistance mechanisms in medulloblastoma
INTRODUCTION Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We analysed whether circumvention of chemoresistance pathways (drug export, DNA repair and apoptotic inhibition) can restore chemotherapeutic efficacy in a panel of MB cell lines. RESULTS We demonstrat...
متن کاملScreening pneumococci for penicillin resistance.
Eighty-four pneumococci with various MICs of penicillin (38 with MICs of less than or equal to 0.06 micrograms/ml [susceptible], 35 with MICs of 0.12 to 1.0 micrograms/ml [relatively resistant], and 11 with MICs of greater than 1.0 micrograms/ml [resistant] ) were screened by a disk diffusion test using oxacillin and methicillin to see how well they distinguished penicillin-susceptible strains ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1954
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.68.5.610-616.1954